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The most common radiosurgery systems include Gamma Knife Systems, modified linear accelerators, and the CyberKnife. Although all of these systems are all capable of delivering the desired radiation dose to a specific area, there are major differences which could significantly impact the treatment and clinical outcome. | | CyberKnife® | GammaKnife® | Other Linac Systems | | Dedicated to Radiosurgery | Yes | Yes | No | | Does Conventional Radiotherapy and/or IMRT | No | No | Yes | | Area treatable with Radiosurgical Precision | Entire Body | Brain and Skull | Varies depending upon specific system | | Rigid Brain or Body Frame Required | No | Yes | Yes | | Lesion Size Limitation | No | Yes | No | Capable of preserving adjacent tissues by dividing treatments | | Yes | No | Yes | | Capable of tracking lesion in real time to follow motion caused by organ movement and breathing with radiosurgical precision | Yes | N/A | No | | | | | | | IMRT dosimetry Method | Yes | No | Yes | IGRT Set-up Visualization | | Yes | No | Yes | | | | | | Capable of conformally and homogeneously treating a
non-spherical target volume > 3.5cm | Yes | No | Yes | | Capable of fractionated radiosurgery to better preserve critical adjacent tissue | Yes | No | Yes | | | | | | | Capable of real-time sub-millimeter translational and rotational beam adaptation to target volume motion | Yes | N/A | No |
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