Serial Tissue	Volume (mL)	Volume Max (Gy)	Max Point Dose (Gy)	Endpoint (Grade 3)
FIVE-FRACTION TREATMENT
Optic pathway	<0.2	20(4Gy/fx)	25(5Gy/fx)	Neuritis
Cochlea			27.5(5.5Gy/fx)	Hearingloss
Brainstem	<1	26(5.2Gy/fx)	31(6.2Gy/fx)	Cranialneuropathy
Spinal cord	<0.25	22.5(4.5Gy/fx)	30(6Gy/fx)	Myelitis
	<1.2	13.5(2.7Gy/fx)
Cauda equina	<5	30(6Gy/fx)	34(6.4Gy/fx)	Neuritis
Sacral plexus	<3	30(6Gy/fx)	32(6.4Gy/fx)	Neuropathy
Esophagus	<5	27.5(5.5Gy/fx)	35(7Gy/fx)	Stenosis/fistula
Ipsilateral brachial plexus	<3	30(6Gy/fx)	32(6.4Gy/fx)	Neuropathy
Heart/pericardium	<15	32(6.4Gy/fx)	38(7.6Gy/fx)	Pericarditis
Great vessels	<10	47(9.4Gy/fx)	53(10.6Gy/fx)	Aneurysm
Trachea and ipsilateral bronchus	<4	18(3.6Gy/fx)	38(7.6Gy/fx)	Stenosis/fistula
Skin	<10	30(6Gy/fx)	32(6.4Gy/fx)	Ulceration
Stomach	<10	28(5.6Gy/fx)	32(6.4Gy/fx)	Ulceration/fistula
Duodenum	<5	18(3.6Gy/fx)	32(6.4Gy/fx)	Ulceration
Jejunum/ileum	<5	19.5(3.9Gy/fx)	35(7Gy/fx)	enteritis/obstruction
Colon	<20	25(5Gy/fx)	38(7.6Gy/fx)	colitis/fistula
Rectum	<20	25(5Gy/fx)	38(7.6Gy/fx)	proctitis/fistula
Bladder wall	<15	18.3(3.65Gy/fx)	38(7.6Gy/fx)	cystitis/fistula
Penile bulb	<3	30(6Gy/fx)	50(10Gy/fx)	Impotence
Femoral heads (right and left)	<10	30(6Gy/fx)		Necrosis
Renal hilum/vascular trunk	<2/3volume	23(4.6Gy/fx)		Malignanthypertension

Parallel Tissue	Critical Volume (mL)	Critical Volume Dose Max (Gy)	Endpoint (Grade 3)
Lung (right and left)	1,500	12.5(2.5Gy/fx)	Basiclungfunction
Lung (right and left)	1000	13.5(2.7Gy/fx)	Pneumonitis
Liver	700	21(4.2Gy/fx)	Basicliverfunction
Renal cortex (right and left)	200	17.5(3.5Gy/fx)	Basicrenalfunction